diff --git a/CMakeLists.txt b/CMakeLists.txt
index 8dc1c757dc..0c19104355 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -34,6 +34,8 @@ endif()
 
 option(ENABLE_CUBEB "Enables the cubeb audio backend" ON)
 
+CMAKE_DEPENDENT_OPTION(ENABLE_LIBUSB "Enable libusb for GameCube Adapter support" ON "NOT IOS" OFF)
+
 option(ENABLE_FFMPEG_AUDIO_DECODER "Enable FFmpeg audio (AAC) decoder" OFF)
 option(ENABLE_FFMPEG_VIDEO_DUMPER "Enable FFmpeg video dumper" OFF)
 
@@ -224,14 +226,16 @@ if (ENABLE_QT)
 endif()
 
 # Ensure libusb is properly configured (based on dolphin libusb include)
-if(NOT APPLE)
-    include(FindPkgConfig)
-    find_package(LibUSB)
-endif()
-if (NOT LIBUSB_FOUND)
-    add_subdirectory(externals/libusb)
-    set(LIBUSB_INCLUDE_DIR "")
-    set(LIBUSB_LIBRARIES usb)
+if (ENABLE_LIBUSB)
+    if(NOT APPLE)
+        include(FindPkgConfig)
+        find_package(LibUSB)
+    endif()
+    if (NOT LIBUSB_FOUND)
+        add_subdirectory(externals/libusb)
+        set(LIBUSB_INCLUDE_DIR "")
+        set(LIBUSB_LIBRARIES usb)
+    endif()
 endif()
 
 if (ENABLE_FFMPEG)
diff --git a/src/input_common/CMakeLists.txt b/src/input_common/CMakeLists.txt
index d03284a238..246e2652bd 100644
--- a/src/input_common/CMakeLists.txt
+++ b/src/input_common/CMakeLists.txt
@@ -1,10 +1,6 @@
 add_library(input_common STATIC
     analog_from_button.cpp
     analog_from_button.h
-    gcadapter/gc_adapter.cpp
-    gcadapter/gc_adapter.h
-    gcadapter/gc_poller.cpp
-    gcadapter/gc_poller.h
     keyboard.cpp
     keyboard.h
     main.cpp
@@ -33,10 +29,20 @@ if(ENABLE_SDL2)
     target_compile_definitions(input_common PRIVATE HAVE_SDL2)
 endif()
 
+if(ENABLE_LIBUSB)
+    target_sources(input_common PRIVATE
+        gcadapter/gc_adapter.cpp
+        gcadapter/gc_adapter.h
+        gcadapter/gc_poller.cpp
+        gcadapter/gc_poller.h
+    )
+    target_include_directories(input_common PRIVATE ${LIBUSB_INCLUDE_DIR})
+    target_link_libraries(input_common PRIVATE ${LIBUSB_LIBRARIES})
+    add_definitions(-DENABLE_GCADAPTER)
+endif()
+
 create_target_directory_groups(input_common)
 target_link_libraries(input_common PUBLIC core PRIVATE common ${Boost_LIBRARIES})
-target_include_directories(input_common PRIVATE ${LIBUSB_INCLUDE_DIR})
-target_link_libraries(input_common PUBLIC ${LIBUSB_LIBRARIES})
 set_target_properties(input_common PROPERTIES INTERPROCEDURAL_OPTIMIZATION ${ENABLE_LTO})
 
 if (CITRA_USE_PRECOMPILED_HEADERS)
diff --git a/src/input_common/main.cpp b/src/input_common/main.cpp
index 26cfc8e610..bcff11d20f 100644
--- a/src/input_common/main.cpp
+++ b/src/input_common/main.cpp
@@ -6,8 +6,10 @@
 #include <thread>
 #include "common/param_package.h"
 #include "input_common/analog_from_button.h"
+#ifdef ENABLE_GCADAPTER
 #include "input_common/gcadapter/gc_adapter.h"
 #include "input_common/gcadapter/gc_poller.h"
+#endif
 #include "input_common/keyboard.h"
 #include "input_common/main.h"
 #include "input_common/motion_emu.h"
@@ -18,20 +20,24 @@
 
 namespace InputCommon {
 
+#ifdef ENABLE_GCADAPTER
 std::shared_ptr<GCButtonFactory> gcbuttons;
 std::shared_ptr<GCAnalogFactory> gcanalog;
 std::shared_ptr<GCAdapter::Adapter> gcadapter;
+#endif
 static std::shared_ptr<Keyboard> keyboard;
 static std::shared_ptr<MotionEmu> motion_emu;
 static std::unique_ptr<CemuhookUDP::State> udp;
 static std::unique_ptr<SDL::State> sdl;
 
 void Init() {
+#ifdef ENABLE_GCADAPTER
     gcadapter = std::make_shared<GCAdapter::Adapter>();
     gcbuttons = std::make_shared<GCButtonFactory>(gcadapter);
     Input::RegisterFactory<Input::ButtonDevice>("gcpad", gcbuttons);
     gcanalog = std::make_shared<GCAnalogFactory>(gcadapter);
     Input::RegisterFactory<Input::AnalogDevice>("gcpad", gcanalog);
+#endif
     keyboard = std::make_shared<Keyboard>();
     Input::RegisterFactory<Input::ButtonDevice>("keyboard", keyboard);
     Input::RegisterFactory<Input::AnalogDevice>("analog_from_button",
@@ -47,10 +53,12 @@ void Init() {
 }
 
 void Shutdown() {
+#ifdef ENABLE_GCADAPTER
     Input::UnregisterFactory<Input::ButtonDevice>("gcpad");
     Input::UnregisterFactory<Input::AnalogDevice>("gcpad");
     gcbuttons.reset();
     gcanalog.reset();
+#endif
     Input::UnregisterFactory<Input::ButtonDevice>("keyboard");
     keyboard.reset();
     Input::UnregisterFactory<Input::AnalogDevice>("analog_from_button");
@@ -99,9 +107,11 @@ Common::ParamPackage GetControllerButtonBinds(const Common::ParamPackage& params
         return dynamic_cast<SDL::SDLState*>(sdl.get())->GetSDLControllerButtonBindByGUID(
             params.Get("guid", "0"), params.Get("port", 0), native_button);
     }
+#ifdef ENABLE_GCADAPTER
     if (engine == "gcpad") {
         return gcbuttons->GetGcTo3DSMappedButton(params.Get("port", 0), native_button);
     }
+#endif
     return {};
 }
 
@@ -112,9 +122,11 @@ Common::ParamPackage GetControllerAnalogBinds(const Common::ParamPackage& params
         return dynamic_cast<SDL::SDLState*>(sdl.get())->GetSDLControllerAnalogBindByGUID(
             params.Get("guid", "0"), params.Get("port", 0), native_analog);
     }
+#ifdef ENABLE_GCADAPTER
     if (engine == "gcpad") {
         return gcanalog->GetGcTo3DSMappedAnalog(params.Get("port", 0), native_analog);
     }
+#endif
     return {};
 }
 
@@ -133,6 +145,7 @@ std::vector<std::unique_ptr<DevicePoller>> GetPollers(DeviceType type) {
 #ifdef HAVE_SDL2
     pollers = sdl->GetPollers(type);
 #endif
+#ifdef ENABLE_GCADAPTER
     switch (type) {
     case DeviceType::Analog:
         pollers.push_back(std::make_unique<GCAnalogFactory>(*gcanalog));
@@ -143,6 +156,7 @@ std::vector<std::unique_ptr<DevicePoller>> GetPollers(DeviceType type) {
     default:
         break;
     }
+#endif
 
     return pollers;
 }